- DEN currently serves 26 international destinations in 11 countries
- Belize City, Belize (BZE) via Southwest Airlines
- Calgary, Canada (YYC) via Frontier, United, WestJet
- Cancun, Mexico (CUN) via Frontier, United, Southwest
- Chihuahua, Mexico (CUU) via Volaris
- Cozumel, Mexico (CZM) via United
- Edmonton, Canada (YEG) via United
- Frankfurt, Germany (FRA) via Lufthansa
- Grand Cayman, Cayman Islands (GCM) via Cayman Airways
- Guadalajara, Mexico (GDL) via Volaris
- Liberia, Costa Rica (LIR) via United
- London, United Kingdom (LGR) via Norwegian
- London, United Kingdom (LHR) via British Airways, United
- Los Cabos, Mexico (SJD) via Frontier, United, Southwest
- Mexico City, Mexico (MEX) via Aeromexico, Volaris
- Monterrey, Mexico (MTY) via Aeromexico
- Montreal, Canada (YUL) via Air Canada
- Munich, Germany (MUC) via Lufthansa
- Panama City, Panama (PTY) via Copa Airlines
- Paris, France (CDG) via Norwegian
- Puerto Vallarta, Mexico (PVR) via Frontier, United, Southwest
- Reykjavik, Iceland (KEF) via Iceland Air
- Tokyo, Japan (NRT) via United
- Toronto, Canada (YVR) via Air Canada, United
- Vancouver, Canada (YWG) via Air Canada, United
- Winnipeg, Canada (YWG) via United
- Zurich, Switzerland (ZRH) via Edelweiss Air
- Passengers can reach more than 190 destinations nonstop from DEN
